Chiral Metallopolymers for Redox‐Mediated Enantioselective Interactions

Synthetic chiral platforms can be a powerful platform for enantioselective interactions, especially when coupled with redox-mediated electrochemical processes. While metallopolymers are versatile molecularly selective binding, their application applications is limited. In particular, the recognition and separation of biologically relevant molecules key biomanufacturing diagnostics. Here, design redox-polymers enables electrochemically-controlled supramolecular chirality leveraged enhancing towards target enantiomers. Chiral redox-metallopolymers synthesized based on Ugi's amine-inspired monomers, toward ionic enantiomers such as tryptophan naproxen demonstrated, higher enanhcement provided by redox-polymer over single-site, building bloack itelf. 2D nuclear magnetic resonance spectroscopy solid-state circular dichroism support emergence resulting from intramolecular interaction between ferrocene alkyl group in backbone. The half potential shift behaves linearly 0% to 100%ee l-tryptophan enable enantiomer quantification. Investigation solvent polarity pH effect reveal that mechanism attributed subtle balance hydrogen bonding π–π interaction. This study highlights electrochemically-modulated interactions range amino acids pharmaceutical carboxylates.